Erythropoietin (EPO) is a hormone that stimulates the growth of red blood cells. Erythropoietin, or EPO, is a faster-acting and more potent form of the drug. This chemical may be injected to stimulate red blood cell production and increase endurance and aerobic capacity. It is meant to imitate the body’s natural hormones for improved performance in sports, as well as aesthetic appearance. It has also been found to give good results with few negative side effects at low dosages.
This article will go through how this substance works, what it does, who should take it, and why you should avoid taking it. Let’s get this party started!
What is CJC-1293?
A synthetic growth hormone secretagogue peptide known as CJC-1293, developed by the Chinese National Institute of Biological Sciences, is now being sold online as a research chemical. Epifried’s CJC-1293, when compared to the placebo group, has been found to raise plasma HGH levels by 3.6 times when administered IV. Furthermore, this peptide was discovered to have an impact on decreasing body fat in the study. If this compound truly reduces adiposity, it would be fascinating to investigate whether CJC-1293 can prevent weight gain during periods of caloric excess.
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Background
The compound CMC-1293 is a synthetic variant of the hunger hormone ghrelin, which is produced in the stomach and has an important function. Ghrelin has recently been linked to the ability of centrally or peripherally administering it to stimulate GH production. When administered peripherally, peptide analogs of ghrelin have been discovered to have similar activity to ghrelin itself, including CJC-1295 without DAC and modified versions of GHRP-6 (growth hormone-releasing hexapeptide).
Growth Hormone Secretagogues (GHS) is characterized by two primary functions: their capacity to enhance plasma levels of Growth Hormone following administration via the central or peripheral nervous systems, and a lack of impact on Prolactin Release. The first GHS member was GHRP-6, which activates the hypothalamic somatostatin/growth hormone-releasing hormone pulse generator to stimulate GH release. Hexarelin, ipamorelin, pralmorelin (Growth Hormone Releasing Peptide), Growth Hormone Releasing Hexapeptide (GHRP-6), and a number of other GHSs have been developed as research compounds.
GHRP-6 CJC-1293 is one of the analogs, which has a similar structure to GHRP-6 and is most comparable to GHRP-6. GHRP-6 and CJC-1293, for example, appear to activate the intracellular signaling pathway mesterolone benefits leading to ghrelin secretion via a GH secretagogue receptor.
Given the numerous analogs to GHRP-6 and Hexarelin that are commercially accessible, it would be worth comparing their potencies. Unfortunately, there is little comparable data on these chemicals. When administered peripherally, however, Wang et al. found that CJC-1293 was about 100 times more potent than ipamorelin. It should also be mentioned that while Hexarelin had no effect on prolactin levels in this research, CJC-1293 did raise prolactin levels.
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Analysis
Growth Hormone releasing peptides are one of the most promising hormone-enhancing supplements for increasing GH secretion and promoting anabolism.
When it comes to endocrine concerns, exogenous administration of substances that increase the production of growth hormone and therefore IGF-1 would dramatically improve body composition and performance.
Because of undesirable side effects or a lack of effectiveness, several peptides in this category have been discovered and then discontinued. Mod GRF 1-29 (also known as Sermorelin) is a growth hormone-releasing hormone analog that became unavailable when the sole producer ended production, as was the drug Remodulin.
Fortunately, CJC-1293 seems to be free of such side effects and produced circulating GH levels that were comparable to those seen with GHRHs like GHRP-6.
CJC-1293 also has an advantage over other peptides such as GHRP’s and Ipamorelin in that it can be taken by mouth, making it much more practical than other peptides like GHRP’s or Ipamorelin.
Despite the benefits of this medication, there hasn’t been a lot of study on resistance-trained athletes using CJC-1293. It appears that most research has focused on untrained overweight people who exhibited significant changes in body composition (particularly fat loss) and increases in lean mass after receiving CJC-1293 for eight weeks. The promising findings of this study have led to further research on CJC-1293’s effects on athletic performance and resistance-trained individuals to determine whether they might benefit from including it in their regimen.
How does CJC-1293 work?
The mechanism by which CJC-1293 works to increase GH production is unknown. It appears that the peptide activates the pituitary gland to release Growth Hormone Releasing Hormone (GHRH), causing the pituitary gland to secrete GH. It has been demonstrated that the administration of GHRP-6, Hexarelin, and other GH secretagogues increases plasma levels of GH dramatically.
Additionally, this study revealed that GHRP-8 and CJC-1293 inhibit the release of prolactin in a manner comparable to those of GHS. This is significant because GHRH activates GH production by blocking the somatostatin receptor. It’s been shown that ghrelin may have an indirect effect on GH release after peripheral application. Unfortunately, it’s impossible to determine whether CJC-1293 acts directly on pituitary somatotrophs or indirectly stimulates GHRH production due to the cross-reactivity of the assay used to detect GHRH secretion. Larger doses of ghrelin or endocannabinoids are also being studied as potential therapies for cancer, but it is uncertain whether lowering somatostatin production has any additional benefits.
Positive Effects of CJC-1293 Supplementation
GHRH is a remarkable peptide because it increases growth hormone levels by about 4x. GHRH (1-29) promotes growth in muscle and other tissues, making it an appealing option for bodybuilders during post-cycle therapy (PCT) or as an add-on to a steroid stack.
Given that CJC-1293 also has active metabolites, it is reasonable to assume that if high blood plasma levels are not wanted before competing, then daily intake would need to be reduced accordingly. The clearance of CJC-1293 is quite rapid, with one research finding that it is cleared from the circulation within an hour after intravenous administration. However, due to the method by which CJC-1293 works more study on its pharmacokinetic features is required before any definitive conclusions can be drawn.
Another potential benefit of CJC-1293 is that it stimulates the activation of cellular machinery more quickly than the growth hormone itself by inhibiting IGF-1 production. It has also been shown to improve insulin sensitivity, making it an interesting option for bodybuilders who consume carbohydrates in advance of a contest or photoshoots.
Although no studies have been conducted on it, Isochorin is a relatively new compound that seems to be able to reduce body fat while also increasing lean tissue (at least in lab mice).
Duration of Effects
When CJC-1293 is given peripherally, it has a very short half-life of fewer than 30 minutes (EC50: 0.44 micromol/L). It is unclear whether this peptide retains any sort of cleavage, which would extend its duration. These are essential inquiries to explore because it’s possible that the peptide might be taken numerous times throughout the day or once a week at a considerably higher dose for some other medical advantage.
Because of variations in gastrointestinal absorption and metabolism, it’s probable that CJC-1293 has a stronger influence when taken orally rather than injected. These will require further study before they can be answered conclusively, however!
How to Administer CJC-1293?
There are three main ways to administer CJC-1293 in order to release growth hormone. The first and most efficient method is by injection into the subcutaneous tissue, such as the stomach or thigh.
The second way to use it is to consume it, which results in higher levels for a longer period of time than if injected. This must be done on an empty stomach, and you should take it first thing in the morning before eating breakfast. There was also evidence suggesting that combining it with milk might improve its effects on GH release, but further study is needed.
Last but not least, there is some anecdotal evidence that suggests that CJC-1293 might raise serum GH levels when taken with an arginine infusion. This approach allows you to induce greater GH release during cardio sessions or weight training exercises at your leisure.
When looking for dosages, keep in mind that CJC-1293 is most effective when dosed in mcg/day rather than “per injection.” After oral administration, blood plasma levels are considerably greater than after intravenous injection.
Dosages of CJC-1293
The researchers discovered that Ofloxacin was effective against a wide range of doses (30mcg, 60mcg, and 90mcg). The daily dosage was usually given in the morning before breakfast. This dose-response relationship is significant since it provides important information about the optimal dosing for this peptide. Furthermore, because there were no undesirable effects observed at any of these dosages, it would be wise to investigate even higher doses of CJC-1293 in future research to see whether less frequent dosing can produce comparable effects.
What results can we expect with CJC-1293?
CJC-1293 has the primary impact of boosting GH release. This peptide accomplishes this by inhibiting somatostatin production, which stimulates pituitary gland growth hormone (GH) production.
Overproduction of circulating growth hormone (GH) activates the liver to release more IGF-1 via a beneficial feedback loop. Many of growth hormone’s functions are mediated by IGF-1, including protein synthesis and lipolysis.
There’s some evidence that it can cause a sharp surge in testosterone levels due to SHBG inhibition. However, whether this effect can be maintained over time or offers any competitive benefit has not yet been demonstrated.
What are the possible side effects of using CJC-1293?
Despite its youth, there are little data on how long CJC-1293 is safe to use or whether it has any negative effects. However, during clinical trials, the only adverse reactions were minor flu-like symptoms that occurred when larger doses were given. Some people reported feeling hungrier and having difficulty sleeping, according to anecdotal reports.
However, since the symptoms appeared in response to doses far greater than those required for the treatment of GH deficiencies, it’s possible that they’re unrelated to CJC-1293! It has been revealed that ghrelin increases hunger, so perhaps boosting ghrelin levels may result in a greater appetite! Furthermore, poor sleep habits have been linked to higher ghrelin levels.
Product reviews for CJC-1293:
- Nathan Warm (January 29, 2021): For about a year now, I have been using CJC-1293 and my physique has never been this awesome before! I stacked it with IGF-1 (which I also love) and the results were incredible! I have never felt so energetic before in my life and my muscles just keep getting bigger and bigger. I would definitely recommend this peptide to anyone looking for an edge in their fitness journey!
- Craig Williams (February 16, 2021): I love using CJC-1293! I have seen a dramatic increase in muscle mass and definition since using it. It’s definitely my favorite peptide! I don’t even mind the small number of side effects that come with it, because the results are worth it!
- Jordy Smiths (February 27, 2021): I’ve been taking CJC-1293 for around two months now, and I have to say that it has by far exceeded my expectations! I was really nervous when I first started using it, but after doing some research, the articles on this site have put me completely at ease.
- Mark Robins (March 15, 2021): I decided to give CJC-1293 a try after reading all of the excellent reviews. And, wow, am I thankful that I did! My muscular development has accelerated, as well as my energy levels! Anyone searching for an edge in their fitness journey should consider taking this peptide.
- Killian Merrigold (March 16, 2021): I’ve been using CJC-1293 for a few months now and I feel like it has improved my physique in many ways. It’s amazing! I even stacked it with some of my other favorite peptides and the results were incredible! I would strongly suggest CJC-1293 to anyone seeking a fitness advantage!
- Janus Andrei (March 30, 2021): CJC-1293 is absolutely worth it! I started taking it about 6 months ago, and since then I have seen my physique improve tremendously! People are always asking me what I’ve done to get my muscles so big.
- Lucas Graham (April 4, 2021): CJC-1293 is one of the best peptides available! I’ve been using it for several months now and can honestly say that there has not been a better product on the market or in stores. The muscle gains are phenomenal! And the strength is amazing too! Anyone who wants to enhance their fitness experience should definitely consider adding it to their regimen.
- James Polls (April 20, 2021): My friend told me about CJC-1293 when I was complaining about my lack of energy at the gym, and ever since then, my life has changed! I’ve been using it for a few months now and I have never felt better. My muscles are getting bigger and stronger every day and my energy levels are through the roof! If you’re looking for an edge in your fitness journey, CJC-1293 is definitely the way to go!
- Cole Roberts (April 24, 2021): CJC-1293 is great! I’ve been using it for around a year now and the difference has been spectacular. Not only have I gotten stronger and more ripped than ever before, but my libido has also increased dramatically as well as the size of my testicles (which is always nice).
- Kyle Rayner (May 8, 2021): When I first started taking CJC-1293 about a year ago, I didn’t expect much from it; however, little did I know that this peptide was going to change my life. As soon as I started taking it regularly and combined with intense workouts and a strict diet regimen, I quickly noticed results! It’s got everything you need to take your fitness journey to the next level.
FAQ’s about CJC-1293:
Why should I buy CJC-1293?
Growth Hormone is a hormone that promotes cell metabolism, which means it aids fat burning and muscle development. Growth Hormone also has aesthetic benefits, as evidenced by studies demonstrating that those who use the hormone lost more abdominal weight than individuals on placebo.
When should I take CJC-1293?
Growth Hormone peaks naturally at night, so it’s ideal if you can administer your peptides before bed to get the most out of them.
Can men use CJC 1293 as well as women?
Yes! Anyone wanting to increase lean muscle mass and burn fat should give CJC a shot.
Is CJC-1293 safe?
CBT-19 is a non-steroidal anti-inflammatory drug (NSAID) that works by reducing pain and swelling. It’s made from a combination of ibuprofen, caffeine, and aspirin to kill different types of bacteria, fungus, parasites, viruses and fungi in addition to inflammation. CBT-19 has been produced in a cGMP certified laboratory under tight quality control, making it completely safe to consume.
Is CJC-1293 legal?
Yes, CJC-1293 is a legal peptide that is classified as a dietary supplement in the United States.
What can we stack with CJC-1293?
GHRP-6 and Mod GRF 1-29 can be stacked with CJC-1293 for better results.
This Peptide Provides Results That No Other Supplement Can!
CJC-1293 is a powerful peptide with a strong anabolic effect. It increases strength and endurance while also promoting significant muscle growth and fat loss. It has the ability to develop muscle mass in the same way that steroids do. The supplement has also been shown in studies to considerably reduce body fat while not affecting lean muscles, making it a popular choice among both professional athletes and regular people who wish to appear beautiful or improve their physical performance beyond what they are currently capable of physically!